The Role of B-Cell Depletion: Analyzing Inebilizumab's Impact...

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2025-12-18 11:04:15 -

The Role of B-Cell Depletion: Analyzing Inebilizumab's Impact on IgG4-RD Outcomes in 2025

B cells have been identified as the primary drivers of the inflammatory storm in IgG4-related disease. Not only do they produce the IgG4 antibodies that give the disease its name, but they also act as messengers that recruit other immune cells to the site of inflammation, leading to the formation of dense, fibrotic masses. In 2025, the strategy of B-cell depletion has moved from the...

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